MolNFT v1 · #177559 · protein
Mooring stone-like ARG114 pulls diverse bulged peptides: first insight into african swine fever virus-derived T cell epitopes presented by swine major histocompatibility complex class I
7EMB · Leucocyte antigen: “Mooring stone-like ARG114 pulls diverse bulged peptides: first insight into african swine fever virus-derived…”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #177559 on GenesisL1: 3D…
- PDB
- 7EMB
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucocyte antigen; Beta-2-microglobulin; Ala-ala-ala-ile-glu-glu-glu-asp-ile
- UniProt
- O19075, Q07717
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucocyte antigen | protein | 275 | 27% helix, 40% strand | O19075 |
| B | Beta-2-microglobulin | protein | 98 | 0% helix, 50% strand | Q07717 |
| C | Ala-ala-ala-ile-glu-glu-glu-asp-ile | protein | 9 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 630 | 0.70 | 0.78 | 62 | empty |
| 2 | 154 | 0.47 | 0.77 | 20 | empty |
| 3 | 95 | 0.43 | 0.78 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1374 Ų buried · 27 hydrogen bonds · protein-protein
- A–C · 804 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7EMB · Mooring Stone-Like Arg114 Pulls Diverse Bulged Peptides: First Insight into African Swine… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07717 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (Q07717) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O19075
- Every structure of UniProt Q07717
- Elsewhere: RCSB PDB 7EMB · PDBe 7EMB · UniProt O19075 · UniProt Q07717
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