MolNFT v1 · #177537 · protein
In situ structure of capping enzyme LAMBDA2, penetration protein MU1 of mammalian reovirus capsid asymmetric unit.
7ELL: “In situ structure of capping enzyme LAMBDA2, penetration protein MU1 of mammalian reovirus capsid asymmetric…”. Electron microscopy, 1 ligand (MYR), 20 pockets (best druggability 0.89). MolNFT v1 #177537 on GenesisL1: 3D structure…
- PDB
- 7ELL
- Type
- protein
- Length
- 7,917 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MU1; MRNA (guanine-N(7)-)-methyltransferase
- EC
- 2.1.1.56, 2.7.7.50
- UniProt
- F1ARM5, A0A0B5CUT9
- Ligands
- MYR
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 7 distinct chains · 31% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MU1 | protein | 41 | 17% helix, 12% strand | F1ARM5 |
| a | MU1 | protein | 610 | 37% helix, 19% strand | F1ARM5 |
| B, C, D, E, F, G, H, J | MU1 | protein | 33 | 18% helix, 12% strand | F1ARM5 |
| b, c, d, e, f, g, i, j | MU1 | protein | 633 | 36% helix, 19% strand | F1ARM5 |
| h | MU1 | protein | 623 | 37% helix, 18% strand | F1ARM5 |
| I | MU1 | protein | 32 | 22% helix, 9% strand | F1ARM5 |
| K | MRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56, 2.7.7.50) | protein | 1283 | 24% helix, 24% strand | A0A0B5CUT9 |
Ligands and binding sites
- MYR · Myristic acid · ligand · 10 copies · chains A, a, K, B, b, C, c, d, E, e, F, f, G, g, h, I, i, J, j
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1083 | 0.89 | 0.90 | 133 | empty |
| 2 | 1054 | 0.88 | 0.90 | 123 | empty |
| 3 | 1080 | 0.88 | 0.89 | 114 | empty |
| 4 | 821 | 0.85 | 0.87 | 89 | empty |
| 5 | 861 | 0.84 | 0.86 | 97 | empty |
Interfaces
67 interfaces between chains.
- d–f · 4681 Ų buried · 36 hydrogen bonds · protein-protein
- a–b · 4642 Ų buried · 39 hydrogen bonds · protein-protein
- d–e · 4605 Ų buried · 44 hydrogen bonds · protein-protein
- g–h · 4603 Ų buried · 44 hydrogen bonds · protein-protein
- g–i · 4561 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 lipid (myristoylation).
Compared structures
- 7ELL · In situ structure of capping enzyme lambda2, penetration protein mu1 of mammalian… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1ARM5
- Every structure of UniProt A0A0B5CUT9
- Elsewhere: RCSB PDB 7ELL · PDBe 7ELL · UniProt F1ARM5 · UniProt A0A0B5CUT9
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