MolNFT v1 · #177528 · protein + RNA
Structure of lassa virus polymerase in complex with 3'-vrna and Z mutant (F36A)
7ELA · Ring finger protein Z: “Structure of lassa virus polymerase in complex with 3'-vrna and Z mutant (F36A)”. Electron microscopy, 2 ligands (ZN, MN), 20 pockets (best druggability 0.80). MolNFT v1 #177528 on GenesisL1: 3D structure…
- PDB
- 7ELA
- Type
- protein + RNA
- Length
- 1,458 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ring finger protein Z; 3-'vrna promoter; RNA-directed RNA polymerase L
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- A0A097F4I8, A0A097F4L1
- Ligands
- ZN, MN
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Ring finger protein Z | protein | 49 | 14% helix, 16% strand | A0A097F4I8 |
| C | 3-'vrna promoter | rna | 7 | — | — |
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1402 | 49% helix, 10% strand | A0A097F4L1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1045 | 0.80 | 0.81 | 98 | empty |
| 2 | 962 | 0.78 | 0.80 | 89 | empty |
| 3 | 135 | 0.73 | 0.93 | 36 | empty |
| 4 | 279 | 0.67 | 0.83 | 32 | empty |
| 5 | 211 | 0.67 | 0.85 | 31 | empty |
Interfaces
2 interfaces between chains.
- C–A · 1018 Ų buried · 16 hydrogen bonds · protein-nucleic
- B–A · 850 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7ELA · Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097F4I8
- Every structure of UniProt A0A097F4L1
- Elsewhere: RCSB PDB 7ELA · PDBe 7ELA · UniProt A0A097F4I8 · UniProt A0A097F4L1
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