MolNFT v1 · #177515 · protein

Crystal structure of the candida glabrata glycogen debranching enzyme (W958A)

7EKU · 4-alpha-glucanotransferase: “Crystal structure of the candida glabrata glycogen debranching enzyme (W958A)”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #177515 on GenesisL1: 3D structure, binding sites and…

PDB: 7EKU
Type: protein
Length: 3,023 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4-alpha-glucanotransferase
EC: 2.4.1.25, 3.2.1.33
UniProt: Q6FSK0
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	4-alpha-glucanotransferase (EC 2.4.1.25, 3.2.1.33)	protein	1525	36% helix, 17% strand	Q6FSK0
B	4-alpha-glucanotransferase (EC 2.4.1.25, 3.2.1.33)	protein	1498	36% helix, 17% strand	Q6FSK0

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	908	0.84	0.85	97	empty
2	1120	0.83	0.84	140	empty
3	599	0.80	0.85	58	empty
4	568	0.73	0.81	66	empty
5	79	0.72	0.96	26	empty

Interfaces

1 interface between chains.

A–B · 231 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

7EKU · Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W958A) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6FSK0
Elsewhere: RCSB PDB 7EKU · PDBe 7EKU · UniProt Q6FSK0

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