MolNFT v1 · #177418 · protein
Structure of human nnmt in complex with macrocyclic peptide 2
7EHZ · Nicotinamide N-methyltransferase: “Structure of human nnmt in complex with macrocyclic peptide 2”. X-ray diffraction. MolNFT v1 #177418 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EHZ
- Type
- protein
- Length
- 245 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nicotinamide N-methyltransferase; Macrocyclic peptide 2
- EC
- 2.1.1.1
- UniProt
- P40261
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nicotinamide N-methyltransferase (EC 2.1.1.1) | protein | 236 | 39% helix, 24% strand | P40261 |
| B | Macrocyclic peptide 2 | protein | 9 | 0% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 783 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (nonstandard).
Compared structures
- 7EHZ · Structure of human NNMT in complex with macrocyclic peptide 2 · the same entry in another collection · chain A against A, TM-score 1.00
- P40261 · AlphaFold monomer V2.0 prediction for nicotinamide N-methyltransferase (P40261) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40261
- Elsewhere: RCSB PDB 7EHZ · PDBe 7EHZ · UniProt P40261
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