MolNFT v1 · #177291 · protein
The crystal structure of the ferm and C-terminal domain complex of drosophila merlin
7EDR · MOESIN/EZRIN/RADIXIN homolog 2: “The crystal structure of the ferm and C-terminal domain complex of drosophila merlin”. X-ray diffraction, 12 pockets (best druggability 0.83). MolNFT v1 #177291 on GenesisL1: 3D structure, binding…
- PDB
- 7EDR
- Type
- protein
- Length
- 849 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MOESIN/EZRIN/RADIXIN homolog 2
- UniProt
- Q24564
- Pockets
- 12 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MOESIN/EZRIN/RADIXIN homolog 2 | protein | 302 | 40% helix, 24% strand | Q24564 |
| C | MOESIN/EZRIN/RADIXIN homolog 2 | protein | 120 | 58% helix, 9% strand | Q24564 |
| B | MOESIN/EZRIN/RADIXIN homolog 2 | protein | 305 | 38% helix, 24% strand | Q24564 |
| D | MOESIN/EZRIN/RADIXIN homolog 2 | protein | 122 | 59% helix, 9% strand | Q24564 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.83 | 0.84 | 123 | empty |
| 2 | 729 | 0.75 | 0.80 | 76 | empty |
| 3 | 724 | 0.71 | 0.78 | 75 | empty |
| 4 | 435 | 0.71 | 0.82 | 39 | empty |
| 5 | 358 | 0.69 | 0.82 | 31 | empty |
Interfaces
6 interfaces between chains.
- B–D · 3004 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 2954 Ų buried · 39 hydrogen bonds · protein-protein
- C–D · 549 Ų buried · 3 hydrogen bonds · protein-protein
- C–B · 55 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 41 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7EDR · The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin · the same entry in another collection · chain D against D, TM-score 1.00
- Q24564 · AlphaFold monomer V2.0 prediction for MOESIN/EZRIN/RADIXIN homolog 2 (Q24564) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q24564
- Elsewhere: RCSB PDB 7EDR · PDBe 7EDR · UniProt Q24564
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