MolNFT v1 · #177278 · protein
Crystal structure of mutant tRNA [GM18] methyltransferase trmh (E107G) in complex with S-adenosyl-L-methionine from escherichia COLI
7EDC · TRNA (GUANOSINE(18)-2'-O)-methyltransferase: “Crystal structure of mutant tRNA [GM18] methyltransferase trmh (E107G) in complex with…”. X-ray diffraction, 2 ligands (SAM, PO4), 2 pockets (best druggability 0.59). MolNFT v1 #177278…
- PDB
- 7EDC
- Type
- protein
- Length
- 236 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (GUANOSINE(18)-2'-O)-methyltransferase
- EC
- 2.1.1.34
- UniProt
- C3SM77
- Ligands
- SAM, PO4
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (GUANOSINE(18)-2'-O)-methyltransferase (EC 2.1.1.34) | protein | 236 | 43% helix, 17% strand | C3SM77 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 243 | 0.59 | 0.79 | 24 | SAM |
| 2 | 53 | 0.27 | 0.75 | 16 | empty |
Compared structures
- 7EDC · Crystal structure of mutant tRNA [Gm18] methyltransferase TrmH (E107G) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C3SM77
- Elsewhere: RCSB PDB 7EDC · PDBe 7EDC · UniProt C3SM77
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