MolNFT v1 · #177267 · protein + RNA
The csy-ACRIF14 complex
7ECV · Type I-F CRISPR-associated endoribonuclease CAS6/CSY4: “The csy-ACRIF14 complex”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #177267 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ECV
- Type
- protein + RNA
- Length
- 3,181 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type I-F CRISPR-associated endoribonuclease CAS6/CSY4; Type I-F CRISPR-associated protein…
- UniProt
- A0A7G9X1S4, A0A3A8DDU9, B3G161, A0A659BSG0, A0A0R6PCL0
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 10 distinct chains · 26% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Type I-F CRISPR-associated endoribonuclease CAS6/CSY4 | protein | 185 | 28% helix, 25% strand | A0A7G9X1S4 |
| A | Type I-F CRISPR-associated protein CSY1 | protein | 424 | 37% helix, 5% strand | A0A3A8DDU9 |
| B | CRISPR type I-F/YPEST-associated protein CSY2 | protein | 305 | 21% helix, 26% strand | B3G161 |
| C | CRISPR-associated protein CSY3 | protein | 293 | 23% helix, 18% strand | A0A659BSG0 |
| D, G | CRISPR-associated protein CSY3 | protein | 333 | 22% helix, 24% strand | A0A659BSG0 |
| E | CRISPR-associated protein CSY3 | protein | 334 | 22% helix, 25% strand | A0A659BSG0 |
| F | CRISPR-associated protein CSY3 | protein | 335 | 24% helix, 22% strand | A0A659BSG0 |
| H | CRISPR-associated protein CSY3 | protein | 331 | 24% helix, 23% strand | A0A659BSG0 |
| I, J | ACRIF14 | protein | 124 | 44% helix, 15% strand | A0A0R6PCL0 |
| M | RNA (60-mer) | rna | 60 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 979 | 0.86 | 0.87 | 136 | empty |
| 2 | 1158 | 0.84 | 0.85 | 116 | empty |
| 3 | 1047 | 0.84 | 0.85 | 134 | empty |
| 4 | 476 | 0.83 | 0.90 | 72 | empty |
| 5 | 421 | 0.82 | 0.90 | 72 | empty |
Interfaces
32 interfaces between chains.
- A–B · 3519 Ų buried · 29 hydrogen bonds · protein-protein
- F–G · 2185 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 2140 Ų buried · 24 hydrogen bonds · protein-protein
- G–H · 2090 Ų buried · 31 hydrogen bonds · protein-protein
- B–H · 2071 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 7ECV · The Csy-AcrIF14 complex · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7G9X1S4
- Every structure of UniProt A0A3A8DDU9
- Every structure of UniProt B3G161
- Every structure of UniProt A0A659BSG0
- Every structure of UniProt A0A0R6PCL0
- Elsewhere: RCSB PDB 7ECV · PDBe 7ECV · UniProt A0A7G9X1S4 · UniProt A0A3A8DDU9 · UniProt B3G161 · UniProt A0A659BSG0 · UniProt A0A0R6PCL0
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