MolNFT v1 · #17719 · protein
Structure of the dimerized cytoplasmic domain of P23 in solution, NMR, 10 structures
1P23 · Transmembrane protein TMP21 precursor: “Structure of the dimerized cytoplasmic domain of P23 in solution, NMR, 10 structures”. Solution nmr, 1 pocket (best druggability 0.62). MolNFT v1 #17719 on GenesisL1: 3D structure, binding…
- PDB
- 1P23
- Type
- protein
- Length
- 56 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protein TMP21 precursor
- UniProt
- Q28735
- Pockets
- 1 · best druggability 0.62
Structure
solution nmr · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transmembrane protein TMP21 precursor | protein | 14 | 79% helix, 0% strand | Q28735 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.62 | 0.81 | 28 | empty |
Interfaces
5 interfaces between chains.
- B–C · 299 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 290 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 170 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 139 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 50 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1P23 · Structure of the dimerized cytoplasmic domain of P23 in solution, NMR, 10 structures · the same entry in another collection · chain A against A, TM-score 1.00
- Q28735 · AlphaFold monomer V2.0 prediction for transmembrane EMP24 domain- containing protein 10… · a predicted model of the same protein · chain A against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28735
- Elsewhere: RCSB PDB 1P23 · PDBe 1P23 · UniProt Q28735
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