MolNFT v1 · #177119 · protein

Cryoem structure of human KV4.2-KCHIP1 complex

7E84 · Potassium voltage-gated channel subfamily D member 2: “Cryoem structure of human KV4.2-KCHIP1 complex”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #177119 on GenesisL1: 3D structure, binding sites and…

PDB: 7E84
Type: protein
Length: 2,548 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium voltage-gated channel subfamily D member 2; Kv channel-interacting protein 1
UniProt: A0A6P6DHQ6, Q9NZI2
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 2 distinct chains · 62% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, G	Potassium voltage-gated channel subfamily D member 2	protein	460	63% helix, 5% strand	A0A6P6DHQ6
E, H, J, L	Kv channel-interacting protein 1	protein	177	56% helix, 4% strand	Q9NZI2

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	841	0.82	0.85	45	empty
2	513	0.81	0.87	36	empty
3	860	0.77	0.80	76	empty
4	1172	0.75	0.77	84	empty
5	1113	0.74	0.77	83	empty

Interfaces

14 interfaces between chains.

A–G · 3424 Å² buried · 21 hydrogen bonds · protein-protein
B–D · 3405 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 3403 Å² buried · 20 hydrogen bonds · protein-protein
D–G · 3400 Å² buried · 21 hydrogen bonds · protein-protein
A–H · 1800 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

7E84 · CryoEM structure of human Kv4.2-KChIP1 complex · the same entry in another collection · chain L against L, TM-score 1.00
Q9NZI2 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q9NZI2) · a predicted model of the same protein · chain E against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6P6DHQ6
Every structure of UniProt Q9NZI2
Elsewhere: RCSB PDB 7E84 · PDBe 7E84 · UniProt A0A6P6DHQ6 · UniProt Q9NZI2

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