MolNFT v1 · #177081 · protein
The crystal structure of foot-and-mouth disease VIRUS(FMDV) 2C protein 97-318AA
7E6V · Protein 2C: “The crystal structure of foot-and-mouth disease VIRUS(FMDV) 2C protein 97-318AA”. X-ray diffraction, 7 pockets (best druggability 0.54). MolNFT v1 #177081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E6V
- Type
- protein
- Length
- 405 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein 2C
- EC
- 2.7.7.48, 3.4.22.28, 3.4.22.46, 3.6.1.15
- UniProt
- B8Y0J7
- Pockets
- 7 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein 2C (EC 2.7.7.48, 3.4.22.28, 3.4.22.46, 3.6.1.15) | protein | 209 | 30% helix, 18% strand | B8Y0J7 |
| B | Protein 2C (EC 2.7.7.48, 3.4.22.28, 3.4.22.46, 3.6.1.15) | protein | 196 | 29% helix, 19% strand | B8Y0J7 |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.54 | 0.83 | 24 | empty |
| 2 | 166 | 0.44 | 0.74 | 32 | empty |
| 3 | 67 | 0.43 | 0.81 | 18 | empty |
| 4 | 163 | 0.42 | 0.74 | 21 | empty |
| 5 | 56 | 0.34 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 464 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 7E6V · The crystal structure of foot-and-mouth disease virus(FMDV) 2C protein 97-318aa · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8Y0J7
- Elsewhere: RCSB PDB 7E6V · PDBe 7E6V · UniProt B8Y0J7
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