MolNFT v1 · #177028 · protein
Interferon-inducible anti-viral protein truncated
7E59 · Guanylate-binding protein 5: “Interferon-inducible anti-viral protein truncated”. X-ray diffraction, 14 pockets (best druggability 0.65). MolNFT v1 #177028 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7E59
- Type
- protein
- Length
- 1,633 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanylate-binding protein 5
- EC
- 3.6.5.-
- UniProt
- Q96PP8
- Pockets
- 14 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 422 | 55% helix, 14% strand | Q96PP8 |
| A | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 391 | 53% helix, 15% strand | Q96PP8 |
| B | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 414 | 55% helix, 13% strand | Q96PP8 |
| C | Guanylate-binding protein 5 (EC 3.6.5.-) | protein | 406 | 55% helix, 13% strand | Q96PP8 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.65 | 0.76 | 54 | empty |
| 2 | 85 | 0.59 | 0.87 | 20 | empty |
| 3 | 489 | 0.59 | 0.74 | 45 | empty |
| 4 | 98 | 0.56 | 0.85 | 22 | empty |
| 5 | 72 | 0.51 | 0.85 | 24 | empty |
Interfaces
1 interface between chains.
- G–A · 1070 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PP8
- Elsewhere: RCSB PDB 7E59 · PDBe 7E59 · UniProt Q96PP8
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