MolNFT v1 · #176983 · protein
Crystal structure of trml from shewanella oneidensis
7E3S · TRNA (CYTIDINE(34)-2'-O)-methyltransferase: “Crystal structure of trml from shewanella oneidensis”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #176983 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7E3S
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA (CYTIDINE(34)-2'-O)-methyltransferase
- EC
- 2.1.1.207
- UniProt
- Q8E8X2
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA (CYTIDINE(34)-2'-O)-methyltransferase (EC 2.1.1.207) | protein | 145 | 36% helix, 19% strand | Q8E8X2 |
| B | TRNA (CYTIDINE(34)-2'-O)-methyltransferase (EC 2.1.1.207) | protein | 155 | 35% helix, 17% strand | Q8E8X2 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 178 | 0.61 | 0.83 | 25 | empty |
| 2 | 255 | 0.59 | 0.79 | 28 | empty |
| 3 | 68 | 0.36 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1397 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7E3S · Crystal structure of TrmL from Shewanella oneidensis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8E8X2
- Elsewhere: RCSB PDB 7E3S · PDBe 7E3S · UniProt Q8E8X2
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