MolNFT v1 · #17687 · protein
Crystal structure of the D2 domain of rptpa
1P15 · Protein-tyrosine phosphatase alpha: “Crystal structure of the D2 domain of rptpa”. X-ray diffraction, 4 pockets (best druggability 0.45). MolNFT v1 #17687 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1P15
- Type
- protein
- Length
- 491 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-tyrosine phosphatase alpha
- EC
- 3.1.3.48
- UniProt
- P18052
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine phosphatase alpha (EC 3.1.3.48) | protein | 245 | 24% helix, 17% strand | P18052 |
| B | Protein-tyrosine phosphatase alpha (EC 3.1.3.48) | protein | 246 | 30% helix, 24% strand | P18052 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.45 | 0.76 | 23 | empty |
| 2 | 63 | 0.41 | 0.81 | 16 | empty |
| 3 | 50 | 0.34 | 0.79 | 10 | empty |
| 4 | 58 | 0.29 | 0.75 | 22 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18052
- Elsewhere: RCSB PDB 1P15 · PDBe 1P15 · UniProt P18052
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