MolNFT v1 · #176761 · protein
Cryo-EM structure of amyloid fibril formed by familial prion disease- related mutation E196K
7DWV · Major prion protein: “Cryo-EM structure of amyloid fibril formed by familial prion disease- related mutation E196K”. Electron microscopy, 4 pockets (best druggability 0.58). MolNFT v1 #176761 on GenesisL1: 3D structure, binding…
- PDB
- 7DWV
- Type
- protein
- Length
- 258 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major prion protein
- UniProt
- P04156
- Pockets
- 4 · best druggability 0.58
Structure
electron microscopy · 1 distinct chain · 0% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Major prion protein | protein | 43 | 0% helix, 16% strand | P04156 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 189 | 0.58 | 0.81 | 27 | empty |
| 2 | 319 | 0.54 | 0.75 | 36 | empty |
| 3 | 301 | 0.53 | 0.75 | 36 | empty |
| 4 | 147 | 0.50 | 0.79 | 30 | empty |
Interfaces
12 interfaces between chains.
- D–E · 1840 Ų buried · 46 hydrogen bonds · protein-protein
- B–C · 1838 Ų buried · 46 hydrogen bonds · protein-protein
- E–F · 1837 Ų buried · 46 hydrogen bonds · protein-protein
- A–B · 1834 Ų buried · 46 hydrogen bonds · protein-protein
- B–D · 144 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7DWV · Cryo-EM structure of amyloid fibril formed by familial prion disease-related mutation… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04156
- Elsewhere: RCSB PDB 7DWV · PDBe 7DWV · UniProt P04156
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