MolNFT v1 · #176737 · protein

Crystal structure of a glutathione S-transferase SBGSTU6 from salix babylonica

7DW2: “Crystal structure of a glutathione S-transferase SBGSTU6 from salix babylonica”. X-ray diffraction, 11 pockets (best druggability 0.81). MolNFT v1 #176737 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7DW2
Type: protein
Length: 880 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase
UniProt: A0A4Y5R032
Pockets: 11 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Glutathione S-transferase	protein	220	57% helix, 9% strand	A0A4Y5R032

Pockets

11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1134	0.81	0.82	102	empty
2	768	0.77	0.81	71	empty
3	724	0.76	0.81	66	empty
4	206	0.55	0.78	40	empty
5	288	0.54	0.75	32	empty

Interfaces

4 interfaces between chains.

C–D · 1140 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1138 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 233 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 232 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7DW2 · Crystal structure of a glutathione S-transferase SbGSTU6 from Salix babylonica · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A4Y5R032
Elsewhere: RCSB PDB 7DW2 · PDBe 7DW2 · UniProt A0A4Y5R032

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