MolNFT v1 · #176411 · protein

Mechanosensitive channel mscs K180R mutant

7DLU · Mechanosensitive ion channel mscs: “Mechanosensitive channel mscs K180R mutant”. Electron microscopy, 20 pockets (best druggability 0.73). MolNFT v1 #176411 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7DLU
Type: protein
Length: 1,820 residues
Chains: 7
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mechanosensitive ion channel mscs
UniProt: Q9HW12
Pockets: 20 · best druggability 0.73

Structure

electron microscopy · 1 distinct chain · 49% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G	Mechanosensitive ion channel mscs	protein	260	49% helix, 22% strand	Q9HW12

Pockets

20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	894	0.73	0.77	90	empty
2	479	0.73	0.82	28	empty
3	1006	0.70	0.74	53	empty
4	362	0.62	0.77	40	empty
5	359	0.61	0.77	42	empty

Interfaces

7 interfaces between chains.

E–F · 2705 Å² buried · 26 hydrogen bonds · protein-protein
A–B · 2703 Å² buried · 26 hydrogen bonds · protein-protein
A–G · 2702 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 2701 Å² buried · 26 hydrogen bonds · protein-protein
F–G · 2700 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

7DLU · Mechanosensitive channel MscS K180R mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HW12
Elsewhere: RCSB PDB 7DLU · PDBe 7DLU · UniProt Q9HW12

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.