MolNFT v1 · #176410 · protein

Cytochrome P450 (CYP105D18) complex with papaverine

7DLS · Cytochrome P450 hydroxylase: “Cytochrome P450 (CYP105D18) complex with papaverine”. X-ray diffraction, 2 ligands (HEM, EV1), 1 pocket (best druggability 0.79). MolNFT v1 #176410 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7DLS
Type: protein
Length: 392 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450 hydroxylase
UniProt: A0A160P685
Ligands: HEM, EV1
Pockets: 1 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450 hydroxylase	protein	392	53% helix, 10% strand	A0A160P685

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
EV1 · 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1021	0.79	0.80	80	HEM, EV1

Compared structures

7DLS · Cytochrome P450 (CYP105D18) complex with papaverine · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A160P685
Elsewhere: RCSB PDB 7DLS · PDBe 7DLS · UniProt A0A160P685

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