MolNFT v1 · #176398 · protein

Crystal structure of nucleoside transporter nupg (D323A mutant)

7DLA · Nucleoside permease nupg: “Crystal structure of nucleoside transporter nupg (D323A mutant)”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #176398 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7DLA
Type: protein
Length: 402 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoside permease nupg
UniProt: P0AFF4
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 80% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoside permease nupg	protein	402	80% helix, 1% strand	P0AFF4

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1004	0.76	0.78	78	empty
2	50	0.27	0.74	16	empty

Compared structures

7DLA · Crystal structure of nucleoside transporter NupG (D323A mutant) · the same entry in another collection · chain A against A, TM-score 1.00
P0AFF4 · AlphaFold monomer V2.0 prediction for nucleoside permease nupg (P0AFF4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AFF4
Elsewhere: RCSB PDB 7DLA · PDBe 7DLA · UniProt P0AFF4

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