MolNFT v1 · #176390 · protein
Cryo-EM structure of human tsc complex
7DL2 · Hamartin: “Cryo-EM structure of human tsc complex”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #176390 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DL2
- Type
- protein
- Length
- 3,089 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hamartin; Isoform 7 of tuberin; TBC1 domain family member 7; Unknown protein
- UniProt
- Q92574, P49815, Q9P0N9
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 6 distinct chains · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Hamartin | protein | 226 | 96% helix, 0% strand | Q92574 |
| A | Isoform 7 of tuberin | protein | 1127 | 51% helix, 7% strand | P49815 |
| B | Isoform 7 of tuberin | protein | 1042 | 54% helix, 6% strand | P49815 |
| C | Hamartin | protein | 224 | 96% helix, 0% strand | Q92574 |
| E | TBC1 domain family member 7 | protein | 267 | 68% helix, 1% strand | Q9P0N9 |
| F | Unknown protein | protein | 203 | 63% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 851 | 0.83 | 0.85 | 80 | empty |
| 2 | 217 | 0.82 | 0.95 | 48 | empty |
| 3 | 226 | 0.81 | 0.94 | 41 | empty |
| 4 | 870 | 0.79 | 0.82 | 115 | empty |
| 5 | 132 | 0.78 | 0.96 | 39 | empty |
Interfaces
10 interfaces between chains.
- A–B · 3953 Ų buried · 57 hydrogen bonds · protein-protein
- D–C · 3727 Ų buried · 18 hydrogen bonds · protein-protein
- D–A · 2066 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 1510 Ų buried · 15 hydrogen bonds · protein-protein
- D–B · 1018 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7DL2 · Cryo-EM structure of human TSC complex · the same entry in another collection · chain E against E, TM-score 1.00
- Q9P0N9 · AlphaFold monomer V2.0 prediction for TBC1 domain family member 7 (Q9P0N9) · a predicted model of the same protein · chain E against A, TM-score 0.98
- P49815 · AlphaFold monomer V2.0 prediction for tuberin (P49815) · a predicted model of the same protein · chain A against A, TM-score 0.90
- Q92574 · AlphaFold monomer V2.0 prediction for hamartin (Q92574) · a predicted model of the same protein · chain D against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92574
- Every structure of UniProt P49815
- Every structure of UniProt Q9P0N9
- Elsewhere: RCSB PDB 7DL2 · PDBe 7DL2 · UniProt Q92574 · UniProt P49815 · UniProt Q9P0N9
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