MolNFT v1 · #176240 · protein
Structure and function of diadenylate cyclase dacm in mycoplasma ovipneumoniae
7DFX · Dac domain-containing protein: “Structure and function of diadenylate cyclase dacm in mycoplasma ovipneumoniae”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #176240 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7DFX
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dac domain-containing protein
- UniProt
- A0A014M399
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dac domain-containing protein | protein | 156 | 35% helix, 27% strand | A0A014M399 |
| B | Dac domain-containing protein | protein | 158 | 35% helix, 25% strand | A0A014M399 |
Ligands and binding sites
- MLA · Malonic acid · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.47 | 0.79 | 19 | MLA |
| 2 | 57 | 0.32 | 0.76 | 13 | MLA |
| 3 | 52 | 0.30 | 0.76 | 15 | MLA |
Interfaces
1 interface between chains.
- A–B · 739 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (additive adduct).
Compared structures
- 7DFX · Structure and function of Diadenylate cyclase DacM in Mycoplasma ovipneumoniae · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A014M399
- Elsewhere: RCSB PDB 7DFX · PDBe 7DFX · UniProt A0A014M399
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