MolNFT v1 · #176125 · protein
Nonstructural protein 7 and 8 complex of SARS-cov-2
7DCD · Non-structural protein 7: “Nonstructural protein 7 and 8 complex of SARS-cov-2”. X-ray diffraction, 11 pockets (best druggability 0.73). MolNFT v1 #176125 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DCD
- Type
- protein
- Length
- 761 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 7; Non-structural protein 8
- UniProt
- P0DTC1
- Pockets
- 11 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 51% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Non-structural protein 7 | protein | 75 | 72% helix, 0% strand | P0DTC1 |
| B, D | Non-structural protein 8 | protein | 116 | 40% helix, 22% strand | P0DTC1 |
| C | Non-structural protein 7 | protein | 76 | 71% helix, 0% strand | P0DTC1 |
| E | Non-structural protein 7 | protein | 76 | 67% helix, 0% strand | P0DTC1 |
| F | Non-structural protein 8 | protein | 113 | 38% helix, 25% strand | P0DTC1 |
| H | Non-structural protein 8 | protein | 114 | 37% helix, 24% strand | P0DTC1 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 756 | 0.73 | 0.79 | 73 | empty |
| 2 | 537 | 0.69 | 0.79 | 63 | empty |
| 3 | 95 | 0.56 | 0.85 | 26 | empty |
| 4 | 329 | 0.54 | 0.74 | 42 | empty |
| 5 | 108 | 0.52 | 0.82 | 14 | empty |
Interfaces
13 interfaces between chains.
- A–B · 1538 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1521 Ų buried · 9 hydrogen bonds · protein-protein
- G–H · 1433 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 1425 Ų buried · 6 hydrogen bonds · protein-protein
- F–H · 304 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7DCD · Nonstructural protein 7 and 8 complex of SARS-CoV-2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC1
- Elsewhere: RCSB PDB 7DCD · PDBe 7DCD · UniProt P0DTC1
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