MolNFT v1 · #176072 · protein

Adenosine triphosphate phosphoribosyltransferase from vibrio cholerae

7DAM · ATP phosphoribosyltransferase: “Adenosine triphosphate phosphoribosyltransferase from vibrio cholerae”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1 #176072 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7DAM
Type: protein
Length: 556 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP phosphoribosyltransferase
EC: 2.4.2.17
UniProt: C3LU29
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP phosphoribosyltransferase (EC 2.4.2.17)	protein	284	33% helix, 27% strand	C3LU29
B	ATP phosphoribosyltransferase (EC 2.4.2.17)	protein	272	33% helix, 26% strand	C3LU29

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1196	0.79	0.81	113	empty
2	152	0.50	0.78	22	empty
3	140	0.48	0.78	26	empty
4	95	0.43	0.78	26	empty
5	98	0.40	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 1000 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

7DAM · Adenosine triphosphate phosphoribosyltransferase from Vibrio cholerae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C3LU29
Elsewhere: RCSB PDB 7DAM · PDBe 7DAM · UniProt C3LU29

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