MolNFT v1 · #175918 · protein
Structure of norc transporter in an outward-open conformation in complex with a single-chain indian camelid antibody
7D5P · Drug transporter, putative: “Structure of norc transporter in an outward-open conformation in complex with a single-chain indian camelid…”. X-ray diffraction, 1 ligand (ZN), 8 pockets (best druggability 0.84). MolNFT v1 #175918 on…
- PDB
- 7D5P
- Type
- protein
- Length
- 1,083 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Drug transporter, putative; Icab
- UniProt
- A0A0H2WZS4
- Ligands
- ZN
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Drug transporter, putative | protein | 408 | 82% helix, 0% strand | A0A0H2WZS4 |
| B | Drug transporter, putative | protein | 413 | 81% helix, 0% strand | A0A0H2WZS4 |
| C, D | Icab | protein | 131 | 2% helix, 53% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 920 | 0.84 | 0.85 | 82 | empty |
| 2 | 1189 | 0.81 | 0.82 | 83 | empty |
| 3 | 65 | 0.72 | 0.97 | 18 | empty |
| 4 | 231 | 0.55 | 0.77 | 30 | empty |
| 5 | 287 | 0.52 | 0.74 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1323 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 1321 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 395 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 30 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 7D5P · Structure of NorC transporter in an outward-open conformation in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H2WZS4
- Elsewhere: RCSB PDB 7D5P · PDBe 7D5P · UniProt A0A0H2WZS4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.