MolNFT v1 · #175913 · protein

Cryoem structure of cotton cellulose synthase isoform 7

7D5K: “Cryoem structure of cotton cellulose synthase isoform 7”. Electron microscopy, 1 ligand (BGC), 20 pockets (best druggability 0.88). MolNFT v1 #175913 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7D5K
Type: protein
Length: 2,181 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cellulose synthase
EC: 2.4.1.12
UniProt: L7NUA2
Ligands: BGC
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 1 distinct chain · 51% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Cellulose synthase (EC 2.4.1.12)	protein	727	51% helix, 9% strand	L7NUA2

Ligands and binding sites

BGC · beta-D-glucopyranose · sugar · 12 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	958	0.88	0.90	96	BGC
2	850	0.87	0.89	100	BGC
3	810	0.87	0.89	96	BGC
4	1032	0.79	0.81	85	empty
5	96	0.67	0.90	17	empty

Interfaces

3 interfaces between chains.

B–C · 1157 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 1140 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 1137 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7D5K · CryoEM structure of cotton cellulose synthase isoform 7 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt L7NUA2
Elsewhere: RCSB PDB 7D5K · PDBe 7D5K · UniProt L7NUA2

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