MolNFT v1 · #17590 · protein

Structural basis of the multiple binding capacity of the acrb multidrug efflux pump

1OY6 · Acriflavine resistance protein B: “Structural basis of the multiple binding capacity of the acrb multidrug efflux pump”. X-ray diffraction, 10 pockets (best druggability 0.83). MolNFT v1 #17590 on GenesisL1: 3D structure, binding…

PDB: 1OY6
Type: protein
Length: 1,006 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acriflavine resistance protein B
UniProt: P31224
Pockets: 10 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acriflavine resistance protein B	protein	1006	48% helix, 16% strand	P31224

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	516	0.83	0.89	56	empty
2	398	0.76	0.86	41	empty
3	169	0.62	0.84	28	empty
4	193	0.57	0.79	24	empty
5	285	0.57	0.76	38	empty

Compared structures

1OY6 · Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump · the same entry in another collection · chain A against A, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Elsewhere: RCSB PDB 1OY6 · PDBe 1OY6 · UniProt P31224

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