MolNFT v1 · #175861 · protein

Crystal structure of the OSPHR2-OSSPX2 complex

7D3Y · Spx domain-containing protein 2,ISOFORM 1 of core histone…: “Crystal structure of the OSPHR2-OSSPX2 complex”. X-ray diffraction, 1 ligand (IHP), 11 pockets (best druggability 0.63). MolNFT v1 #175861 on GenesisL1: 3D structure…

PDB: 7D3Y
Type: protein
Length: 910 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spx domain-containing protein 2,ISOFORM 1 of core histone macro-H2A.1; Protein phosphate…
UniProt: A2X254, Q6Z156
Ligands: IHP
Pockets: 11 · best druggability 0.63

Structure

x-ray diffraction · 5 distinct chains · 63% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spx domain-containing protein 2,ISOFORM 1 of core histone macro-H2A.1	protein	341	59% helix, 12% strand	A2X254
B	Spx domain-containing protein 2,ISOFORM 1 of core histone macro-H2A.1	protein	337	58% helix, 12% strand	A2X254
C	Protein phosphate starvation response 2	protein	103	76% helix, 0% strand	Q6Z156
D	Protein phosphate starvation response 2	protein	94	71% helix, 0% strand	Q6Z156
E	Protein phosphate starvation response 2	protein	35	94% helix, 0% strand	Q6Z156

Ligands and binding sites

IHP · Inositol hexakisphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.63	0.92	15	empty
2	174	0.61	0.83	19	empty
3	311	0.56	0.75	34	empty
4	81	0.53	0.85	18	empty
5	171	0.52	0.79	28	empty

Interfaces

8 interfaces between chains.

A–B · 4517 Å² buried · 41 hydrogen bonds · protein-protein
B–C · 1303 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 1144 Å² buried · 10 hydrogen bonds · protein-protein
C–E · 910 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 848 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7D3Y · Crystal structure of the osPHR2-osSPX2 complex · the same entry in another collection · chain E against E, TM-score 1.00
Q6Z156 · AlphaFold monomer V2.0 prediction for protein phosphate starvation response 2 (Q6Z156) · a predicted model of the same protein · chain E against A, TM-score 0.91
A2X254 · AlphaFold monomer V2.0 prediction for spx domain-containing protein 2 (A2X254) · a predicted model of the same protein · chain A against A, TM-score 0.25

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A2X254
Every structure of UniProt Q6Z156
Elsewhere: RCSB PDB 7D3Y · PDBe 7D3Y · UniProt A2X254 · UniProt Q6Z156

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.