MolNFT v1 · #175852 · protein
Foot and mouth disease virus O/TIBET/99-bound the single chain fragmen antibody F145
7D3L · O/TIBET/99 VP1: “Foot and mouth disease virus O/TIBET/99-bound the single chain fragmen antibody F145”. Electron microscopy, 7 pockets (best druggability 0.75). MolNFT v1 #175852 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7D3L
- Type
- protein
- Length
- 898 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O/TIBET/99 VP1; O/TIBET/99 VP2; O/TIBET/99 VP3; O/TIBET/99 VP4; F145 vh; F145 vl
- Pockets
- 7 · best druggability 0.75
Structure
electron microscopy · 6 distinct chains · 6% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | O/TIBET/99 VP1 | protein | 183 | 4% helix, 25% strand | — |
| 2 | O/TIBET/99 VP2 | protein | 206 | 4% helix, 37% strand | — |
| 3 | O/TIBET/99 VP3 | protein | 219 | 9% helix, 26% strand | — |
| 4 | O/TIBET/99 VP4 | protein | 45 | 24% helix, 0% strand | — |
| H | F145 vh | protein | 137 | 4% helix, 25% strand | — |
| L | F145 vl | protein | 108 | 3% helix, 43% strand | — |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 848 | 0.75 | 0.79 | 73 | empty |
| 2 | 571 | 0.70 | 0.79 | 54 | empty |
| 3 | 143 | 0.43 | 0.75 | 26 | empty |
| 4 | 110 | 0.41 | 0.77 | 23 | empty |
| 5 | 113 | 0.40 | 0.75 | 20 | empty |
Interfaces
8 interfaces between chains.
- H–L · 1267 Ų buried · 25 hydrogen bonds · protein-protein
- 1–2 · 1260 Ų buried · 20 hydrogen bonds · protein-protein
- 1–3 · 1053 Ų buried · 13 hydrogen bonds · protein-protein
- 2–3 · 890 Ų buried · 12 hydrogen bonds · protein-protein
- 1–4 · 828 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7D3L · Foot and mouth disease virus O/TIBET/99-bound the single chain fragmen antibody F145 · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7D3L · PDBe 7D3L
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.