MolNFT v1 · #175811 · protein
Tetrameric coiled-coil structure of liprin-ALPHA2_H3
7D2E · Liprin-alpha-2: “Tetrameric coiled-coil structure of liprin-ALPHA2_H3”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #175811 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7D2E
- Type
- protein
- Length
- 242 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Liprin-alpha-2
- UniProt
- O75334
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 4 distinct chains · 96% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Liprin-alpha-2 | protein | 62 | 95% helix, 0% strand | O75334 |
| B | Liprin-alpha-2 | protein | 58 | 97% helix, 0% strand | O75334 |
| C | Liprin-alpha-2 | protein | 59 | 97% helix, 0% strand | O75334 |
| D | Liprin-alpha-2 | protein | 63 | 97% helix, 0% strand | O75334 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.33 | 0.76 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1413 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 1364 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 365 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 364 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 310 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75334
- Elsewhere: RCSB PDB 7D2E · PDBe 7D2E · UniProt O75334
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