Crystal structure of FIP200 CLAW/P-CCPG1 FIR2

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 39% strand (DSSP).

Ligands and binding sites

• GO9 · 3-(2-hydroxyethyloxy)-2-[2-(2-hydroxyethyloxy) ethoxymethyl]-2-(2-hydroxyethyloxymethyl)propan-1-ol · ligand · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 617 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

• 7D0E · Crystal structure of FIP200 Claw/p-CCPG1 FIR2 · the same entry in another collection · chain A against A, TM-score 1.00
• Q8TDY2 · AlphaFold monomer V2.0 prediction for RB1-inducible coiled-coil protein 1 (Q8TDY2) · a predicted model of the same protein · chain A against A, TM-score 0.92
• Q9ULG6 · AlphaFold monomer V2.0 prediction for cell cycle progression protein 1 (Q9ULG6) · a predicted model of the same protein · chain B against A, TM-score 0.22

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8TDY2
• Every structure of UniProt Q9ULG6
• Elsewhere: RCSB PDB 7D0E · PDBe 7D0E · UniProt Q8TDY2 · UniProt Q9ULG6