MolNFT v1 · #175655 · protein

The ligand-free structure of human ppargamma lbd R288C mutant in the presence of the src-1 coactivator peptide

7CXJ · Peroxisome proliferator-activated receptor gamma: “The ligand-free structure of human ppargamma lbd R288C mutant in the presence of the src-1 coactivator peptide”. X-ray diffraction, 2 pockets (best druggability 0.82). MolNFT v1…

PDB: 7CXJ
Type: protein
Length: 270 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma; 16-mer peptide from nuclear receptor…
EC: 2.3.1.48
UniProt: P37231, Q15788
Pockets: 2 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	259	66% helix, 5% strand	P37231
B	16-mer peptide from nuclear receptor coactivator 1 (EC 2.3.1.48)	protein	11	73% helix, 0% strand	Q15788

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	568	0.82	0.87	61	empty
2	52	0.30	0.76	10	empty

Interfaces

1 interface between chains.

A–B · 626 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

7CXJ · The ligand-free structure of human PPARgamma LBD R288C mutant in the presence of the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Every structure of UniProt Q15788
Elsewhere: RCSB PDB 7CXJ · PDBe 7CXJ · UniProt P37231 · UniProt Q15788

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