MolNFT v1 · #175511 · protein + DNA

Pseudomonas aeruginosa antitoxin higa with PA2440 promoter

7CSW · Hth CRO/C1-type domain-containing protein: “Pseudomonas aeruginosa antitoxin higa with PA2440 promoter”. X-ray diffraction, 1 pocket (best druggability 0.66). MolNFT v1 #175511 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7CSW
Type: protein + DNA
Length: 198 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth CRO/C1-type domain-containing protein; PA2440
UniProt: Q9HVC1
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Hth CRO/C1-type domain-containing protein	protein	92	73% helix, 0% strand	Q9HVC1
C	PA2440	dna	7	—	—
D	PA2440	dna	7	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	735	0.66	0.75	48	empty

Interfaces

3 interfaces between chains.

B–A · 1512 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 311 Å² buried · 35 hydrogen bonds · nucleic-nucleic
B–C · 299 Å² buried · 7 hydrogen bonds · protein-nucleic

Compared structures

7CSW · Pseudomonas aeruginosa antitoxin HigA with pa2440 promoter · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HVC1
Elsewhere: RCSB PDB 7CSW · PDBe 7CSW · UniProt Q9HVC1

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