Human SIRT6 in complex with allosteric activator mdl-801 (3.2A)

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · chains A, C
• 8L9 · 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid · ligand · chains A
• G4X · hexadecanethial · ligand · chains A, C
• ZN · Zinc ion · metal · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A, C
• GOL · Glycerol · additive · 4 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7CL1 · Human SIRT6 in complex with allosteric activator MDL-801 (3.2A) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8N6T7
• Elsewhere: RCSB PDB 7CL1 · PDBe 7CL1 · UniProt Q8N6T7