MolNFT v1 · #175095 · protein

Cryo-EM structure of the flagellar export apparatus with flie from salmonella

7CG4 · Flagellar hook-basal body complex protein flie: “Cryo-EM structure of the flagellar export apparatus with flie from salmonella”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #175095 on GenesisL1: 3D structure…

PDB: 7CG4
Type: protein
Length: 1,419 residues
Chains: 11
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flagellar hook-basal body complex protein flie; Flagellar biosynthetic protein flip
UniProt: P26462, P54700
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 8 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
a	Flagellar hook-basal body complex protein flie	protein	71	77% helix, 0% strand	P26462
b	Flagellar hook-basal body complex protein flie	protein	70	77% helix, 0% strand	P26462
c, d, e	Flagellar hook-basal body complex protein flie	protein	72	83% helix, 0% strand	P26462
f	Flagellar hook-basal body complex protein flie	protein	39	77% helix, 0% strand	P26462
r, s	Flagellar biosynthetic protein flip	protein	207	75% helix, 0% strand	P54700
t	Flagellar biosynthetic protein flip	protein	206	76% helix, 0% strand	P54700
u	Flagellar biosynthetic protein flip	protein	203	80% helix, 0% strand	P54700
v	Flagellar biosynthetic protein flip	protein	200	77% helix, 0% strand	P54700

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	768	0.81	0.84	73	empty
2	262	0.68	0.83	31	empty
3	491	0.66	0.77	74	empty
4	314	0.66	0.81	50	empty
5	165	0.63	0.84	25	empty

Interfaces

23 interfaces between chains.

r–t · 1592 Å² buried · 2 hydrogen bonds · protein-protein
t–u · 1564 Å² buried · 1 hydrogen bond · protein-protein
r–s · 1531 Å² buried · 1 hydrogen bond · protein-protein
u–v · 1450 Å² buried · 0 hydrogen bonds · protein-protein
e–u · 738 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

7CG4 · Cryo-EM structure of the flagellar export apparatus with FliE from Salmonella · the same entry in another collection · chain v against v, TM-score 1.00
P26462 · AlphaFold monomer V2.0 prediction for flagellar hook-basal body complex protein flie… · a predicted model of the same protein · chain b against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26462
Every structure of UniProt P54700
Elsewhere: RCSB PDB 7CG4 · PDBe 7CG4 · UniProt P26462 · UniProt P54700

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