MolNFT v1 · #175034 · protein + DNA
Complex structure of transcription factor sghr with its cognate DNA
7CE1 · Laci-type transcription factor: “Complex structure of transcription factor sghr with its cognate DNA”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #175034 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7CE1
- Type
- protein + DNA
- Length
- 4,040 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Laci-type transcription factor; Promoter DNA
- UniProt
- A0A2I4PGE9
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 14 distinct chains · 44% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G, H | Laci-type transcription factor | protein | 331 | 43% helix, 16% strand | A0A2I4PGE9 |
| B | Laci-type transcription factor | protein | 328 | 45% helix, 16% strand | A0A2I4PGE9 |
| a, b, c, d, o | Promoter DNA | dna | 18 | — | — |
| C | Laci-type transcription factor | protein | 332 | 43% helix, 18% strand | A0A2I4PGE9 |
| D | Laci-type transcription factor | protein | 327 | 46% helix, 16% strand | A0A2I4PGE9 |
| g, h, k, l, p | Promoter DNA | dna | 17 | — | — |
| K | Laci-type transcription factor | protein | 333 | 43% helix, 17% strand | A0A2I4PGE9 |
| L | Laci-type transcription factor | protein | 329 | 43% helix, 16% strand | A0A2I4PGE9 |
| O | Laci-type transcription factor | protein | 320 | 46% helix, 12% strand | A0A2I4PGE9 |
| P | Laci-type transcription factor | protein | 324 | 41% helix, 14% strand | A0A2I4PGE9 |
| S | Laci-type transcription factor | protein | 259 | 47% helix, 7% strand | A0A2I4PGE9 |
| T | Laci-type transcription factor | protein | 292 | 46% helix, 9% strand | A0A2I4PGE9 |
| s | Promoter DNA | dna | 14 | — | — |
| t | Promoter DNA | dna | 14 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 770 | 0.83 | 0.86 | 88 | empty |
| 2 | 981 | 0.83 | 0.84 | 107 | empty |
| 3 | 1086 | 0.82 | 0.83 | 113 | empty |
| 4 | 459 | 0.81 | 0.89 | 55 | empty |
| 5 | 637 | 0.80 | 0.85 | 79 | empty |
Interfaces
47 interfaces between chains.
- C–D · 1932 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1926 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 1912 Ų buried · 11 hydrogen bonds · protein-protein
- K–L · 1886 Ų buried · 10 hydrogen bonds · protein-protein
- O–P · 1776 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7CE1 · Complex STRUCTURE OF TRANSCRIPTION FACTOR SghR with its COGNATE DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2I4PGE9
- Elsewhere: RCSB PDB 7CE1 · PDBe 7CE1 · UniProt A0A2I4PGE9
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