MolNFT v1 · #175003 · protein + DNA
MAPE1-recessed dsdna product complex
7CD6 · DNA-(apurinic or apyrimidinic site) endonuclease: “MAPE1-recessed dsdna product complex”. X-ray diffraction, 2 pockets (best druggability 0.59). MolNFT v1 #175003 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7CD6
- Type
- protein + DNA
- Length
- 286 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-(apurinic or apyrimidinic site) endonuclease; DNA…
- EC
- 3.1.-.-
- UniProt
- P28352
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-) | protein | 277 | 29% helix, 25% strand | P28352 |
| B | DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*AP*C)-3') | dna | 9 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.59 | 0.81 | 36 | empty |
| 2 | 58 | 0.34 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 257 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28352
- Elsewhere: RCSB PDB 7CD6 · PDBe 7CD6 · UniProt P28352
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