MolNFT v1 · #174922 · protein

Versatile cis-prenyltransferase MM_0014 from methanosarcina mazei (crystal type: substrate-free)

7CAQ: “Versatile cis-prenyltransferase MM_0014 from methanosarcina mazei (crystal type: substrate-free)”. X-ray diffraction, 2 ligands (PLM, PO4), 5 pockets (best druggability 0.81). MolNFT v1 #174922 on GenesisL1: 3D structure, binding…

PDB: 7CAQ
Type: protein
Length: 415 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cis-prenyltransferase MM_0014
Ligands: PLM, PO4
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cis-prenyltransferase MM_0014	protein	215	42% helix, 17% strand	—
B	Cis-prenyltransferase MM_0014	protein	200	40% helix, 17% strand	—

Ligands and binding sites

PLM · Palmitic acid · ligand · chains A, B
PO4 · Phosphate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.81	0.96	36	PLM, PO4
2	307	0.76	0.87	41	PO4
3	75	0.32	0.75	17	empty
4	57	0.28	0.74	11	empty
5	51	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1466 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

7CAQ · Versatile cis-prenyltransferase MM_0014 from Methanosarcina mazei (crystal type… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7CAQ · PDBe 7CAQ

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