MolNFT v1 · #174861 · protein
Structural and functional characterization of human group a rotavirus P[25] VP8*
7C8P · Outer capsid protein VP4: “Structural and functional characterization of human group a rotavirus P[25] VP8*”. X-ray diffraction, 2 pockets (best druggability 0.69). MolNFT v1 #174861 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7C8P
- Type
- protein
- Length
- 322 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer capsid protein VP4
- UniProt
- M1GR78
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Outer capsid protein VP4 | protein | 161 | 8% helix, 56% strand | M1GR78 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.69 | 0.84 | 45 | empty |
| 2 | 168 | 0.49 | 0.77 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 811 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7C8P · Structural and functional characterization of human group A rotavirus P[25] VP8* · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M1GR78
- Elsewhere: RCSB PDB 7C8P · PDBe 7C8P · UniProt M1GR78
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