MolNFT v1 · #174849 · protein
Cryo-EM structure of cat ACE2 and SARS-cov-2 rbd
7C8D · Angiotensin-converting enzyme 2: “Cryo-EM structure of cat ACE2 and SARS-cov-2 rbd”. Electron microscopy, 1 ligand (ZN), 5 pockets (best druggability 0.70). MolNFT v1 #174849 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7C8D
- Type
- protein
- Length
- 792 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiotensin-converting enzyme 2; Spike protein S1
- EC
- 3.4.17.23
- UniProt
- Q56H28, P0DTC2
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.70
Structure
electron microscopy · 2 distinct chains · 46% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Angiotensin-converting enzyme 2 (EC 3.4.17.23) | protein | 597 | 58% helix, 3% strand | Q56H28 |
| B | Spike protein S1 | protein | 195 | 10% helix, 28% strand | P0DTC2 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.70 | 0.75 | 76 | empty |
| 2 | 569 | 0.67 | 0.77 | 59 | empty |
| 3 | 350 | 0.57 | 0.76 | 43 | empty |
| 4 | 54 | 0.47 | 0.85 | 19 | empty |
| 5 | 52 | 0.33 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1018 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56H28
- Every structure of UniProt P0DTC2
- Elsewhere: RCSB PDB 7C8D · PDBe 7C8D · UniProt Q56H28 · UniProt P0DTC2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.