MolNFT v1 · #174731 · protein + DNA
Crystal structure of dbd plasma treated zebrafish TRF2 myb-domain complexed with DNA
7C4P · Telomere repeat factor a: “Crystal structure of dbd plasma treated zebrafish TRF2 myb-domain complexed with DNA”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #174731 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7C4P
- Type
- protein + DNA
- Length
- 156 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomere repeat factor a; DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'); DNA…
- UniProt
- Q8JGS4, Q4QRH9
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 5 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomere repeat factor a | protein | 55 | 64% helix, 0% strand | Q8JGS4 |
| C | DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3') | dna | 12 | — | — |
| D, F | DNA (5'-D(*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*A)-3') | dna | 12 | — | — |
| B | Terfa protein | protein | 55 | 62% helix, 0% strand | Q4QRH9 |
| E | DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') | dna | 10 | — | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.50 | 0.75 | 24 | empty |
| 2 | 125 | 0.50 | 0.81 | 16 | empty |
| 3 | 54 | 0.28 | 0.75 | 11 | empty |
| 4 | 56 | 0.28 | 0.75 | 8 | empty |
Interfaces
8 interfaces between chains.
- C–D · 539 Ų buried · 49 hydrogen bonds · nucleic-nucleic
- A–D · 485 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–C · 477 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–F · 473 Ų buried · 9 hydrogen bonds · protein-nucleic
- E–F · 450 Ų buried · 38 hydrogen bonds · nucleic-nucleic
Compared structures
- 7C4P · Crystal structure of DBD plasma treated zebrafish TRF2 myb-domain complexed with DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8JGS4
- Every structure of UniProt Q4QRH9
- Elsewhere: RCSB PDB 7C4P · PDBe 7C4P · UniProt Q8JGS4 · UniProt Q4QRH9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.