MolNFT v1 · #174660 · protein
Crystal structure of NSP16-NSP10 heterodimer from SARS-cov-2 in complex with SAM (with additional SAM during crystallization)
7C2I · 2'-O-methyltransferase: “Crystal structure of NSP16-NSP10 heterodimer from SARS-cov-2 in complex with SAM (with additional SAM during…”. X-ray diffraction, 2 ligands (SAM, ZN), 6 pockets (best druggability 0.57). MolNFT v1 #174660…
- PDB
- 7C2I
- Type
- protein
- Length
- 414 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2'-O-methyltransferase; Non-structural protein 10
- EC
- 2.1.1.-
- UniProt
- P0DTD1
- Ligands
- SAM, ZN
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2'-O-methyltransferase (EC 2.1.1.-) | protein | 298 | 28% helix, 21% strand | P0DTD1 |
| B | Non-structural protein 10 | protein | 116 | 24% helix, 15% strand | P0DTD1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 351 | 0.57 | 0.75 | 47 | SAM |
| 2 | 129 | 0.49 | 0.79 | 19 | empty |
| 3 | 60 | 0.35 | 0.78 | 15 | empty |
| 4 | 62 | 0.29 | 0.74 | 17 | empty |
| 5 | 66 | 0.27 | 0.72 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 940 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7C2I · Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7C2I · PDBe 7C2I · UniProt P0DTD1
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