MolNFT v1 · #174639 · protein
Unliganded structure of pseudouridine kinase (puki) from arabidopsis thaliana
7C1X · Pfkb-like carbohydrate kinase family protein: “Unliganded structure of pseudouridine kinase (puki) from arabidopsis thaliana”. X-ray diffraction, 1 ligand (NA), 5 pockets (best druggability 0.77). MolNFT v1 #174639 on GenesisL1: 3D…
- PDB
- 7C1X
- Type
- protein
- Length
- 706 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pfkb-like carbohydrate kinase family protein
- UniProt
- Q94AT3
- Ligands
- NA
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pfkb-like carbohydrate kinase family protein | protein | 353 | 40% helix, 20% strand | Q94AT3 |
| B | Pfkb-like carbohydrate kinase family protein | protein | 353 | 41% helix, 22% strand | Q94AT3 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.77 | 0.82 | 59 | empty |
| 2 | 574 | 0.66 | 0.77 | 53 | empty |
| 3 | 186 | 0.51 | 0.77 | 32 | empty |
| 4 | 241 | 0.51 | 0.75 | 36 | empty |
| 5 | 78 | 0.44 | 0.80 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1256 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 modified (engineered).
Compared structures
- 7C1X · Unliganded structure of Pseudouridine kinase (PUKI) from Arabidopsis thaliana · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94AT3
- Elsewhere: RCSB PDB 7C1X · PDBe 7C1X · UniProt Q94AT3
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