MolNFT v1 · #174578 · protein

DXPS

7BZX · 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic: “DXPS”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #174578 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7BZX
Type: protein
Length: 1,154 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
EC: 2.2.1.7
UniProt: Q38854
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 2 distinct chains · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic (EC 2.2.1.7)	protein	582	42% helix, 17% strand	Q38854
A	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic (EC 2.2.1.7)	protein	572	42% helix, 17% strand	Q38854

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	274	0.84	0.96	84	empty
2	742	0.84	0.87	110	empty
3	255	0.83	0.95	81	empty
4	875	0.82	0.84	140	empty
5	1199	0.81	0.82	170	empty

Interfaces

1 interface between chains.

B–A · 1849 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7BZX · DXPS · the same entry in another collection · chain B against B, TM-score 1.00
Q38854 · AlphaFold monomer V2.0 prediction for 1-deoxy-D-xylulose-5-phosphate synthase… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q38854
Elsewhere: RCSB PDB 7BZX · PDBe 7BZX · UniProt Q38854

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