MolNFT v1 · #174551 · protein
The mutant variant of pngm-1. H96 was substituted for alanine to study metal coordination.
7BZ1 · Metallo-beta-lactamase pngm-1: “The mutant variant of pngm-1. H96 was substituted for alanine to study metal coordination.”. X-ray diffraction, 1 ligand (ZN), 20 pockets (best druggability 0.77). MolNFT v1 #174551 on GenesisL1: 3D…
- PDB
- 7BZ1
- Type
- protein
- Length
- 1,460 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metallo-beta-lactamase pngm-1
- EC
- 3.5.2.6
- UniProt
- A0A2U8UYM6
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Metallo-beta-lactamase pngm-1 (EC 3.5.2.6) | protein | 365 | 30% helix, 24% strand | A0A2U8UYM6 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 683 | 0.77 | 0.82 | 56 | empty |
| 2 | 392 | 0.75 | 0.86 | 61 | empty |
| 3 | 374 | 0.75 | 0.86 | 50 | empty |
| 4 | 724 | 0.75 | 0.80 | 51 | empty |
| 5 | 676 | 0.74 | 0.80 | 53 | empty |
Interfaces
6 interfaces between chains.
- B–C · 5051 Ų buried · 73 hydrogen bonds · protein-protein
- A–D · 4999 Ų buried · 76 hydrogen bonds · protein-protein
- C–D · 1231 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1217 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 606 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7BZ1 · The mutant variant of PNGM-1. H96 was substituted for alanine to study metal coordination. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U8UYM6
- Elsewhere: RCSB PDB 7BZ1 · PDBe 7BZ1 · UniProt A0A2U8UYM6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.