MolNFT v1 · #17453 · protein
Precorrin-8X methylmutase related protein
1OU0: “Precorrin-8X methylmutase related protein”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #17453 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1OU0
- Type
- protein
- Length
- 765 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Precorrin-8X methylmutase related protein
- EC
- 5.4.1.2
- UniProt
- Q9HKE7
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 57% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Precorrin-8X methylmutase related protein (EC 5.4.1.2) | protein | 190 | 58% helix, 12% strand | Q9HKE7 |
| B | Precorrin-8X methylmutase related protein (EC 5.4.1.2) | protein | 193 | 56% helix, 11% strand | Q9HKE7 |
| C, D | Precorrin-8X methylmutase related protein (EC 5.4.1.2) | protein | 191 | 57% helix, 12% strand | Q9HKE7 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.80 | 0.96 | 40 | empty |
| 2 | 379 | 0.64 | 0.79 | 49 | empty |
| 3 | 278 | 0.63 | 0.80 | 41 | empty |
| 4 | 234 | 0.60 | 0.80 | 29 | empty |
| 5 | 228 | 0.59 | 0.80 | 33 | empty |
Interfaces
6 interfaces between chains.
- B–C · 803 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 787 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 732 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 678 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 276 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
- 1OU0 · precorrin-8X methylmutase related protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HKE7
- Elsewhere: RCSB PDB 1OU0 · PDBe 1OU0 · UniProt Q9HKE7
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