MolNFT v1 · #174453 · protein

Dfga-dfgb complex apo

7BVS · Sugar phosphate ISOMERASE/EPIMERASE: “Dfga-dfgb complex apo”. X-ray diffraction, 2 ligands (MN, SO4), 7 pockets (best druggability 0.60). MolNFT v1 #174453 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7BVS
Type: protein
Length: 441 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sugar phosphate ISOMERASE/EPIMERASE; Dfgb
UniProt: I5AX50, I5AX49
Ligands: MN, SO4
Pockets: 7 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sugar phosphate ISOMERASE/EPIMERASE	protein	290	43% helix, 18% strand	I5AX50
B	Dfgb	protein	151	13% helix, 38% strand	I5AX49

Ligands and binding sites

MN · Manganese (II) ion · metal · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A, B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.60	0.89	20	empty
2	54	0.52	0.87	15	empty
3	197	0.50	0.77	25	SO4
4	167	0.44	0.75	28	empty
5	101	0.40	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 888 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7BVS · DfgA-DfgB complex apo · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I5AX50
Every structure of UniProt I5AX49
Elsewhere: RCSB PDB 7BVS · PDBe 7BVS · UniProt I5AX50 · UniProt I5AX49

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.