MolNFT v1 · #174432 · protein
INTS3 complexed with INTS6
7BV7 · Integrator complex subunit 3: “INTS3 complexed with INTS6”. X-ray diffraction, 10 pockets (best druggability 0.79). MolNFT v1 #174432 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7BV7
- Type
- protein
- Length
- 758 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrator complex subunit 3; Integrator complex subunit 6
- UniProt
- Q68E01, Q9UL03
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrator complex subunit 3 | protein | 336 | 70% helix, 0% strand | Q68E01 |
| B | Integrator complex subunit 3 | protein | 348 | 70% helix, 0% strand | Q68E01 |
| C | Integrator complex subunit 6 | protein | 74 | 76% helix, 0% strand | Q9UL03 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.79 | 0.98 | 29 | empty |
| 2 | 271 | 0.53 | 0.76 | 42 | empty |
| 3 | 149 | 0.43 | 0.75 | 20 | empty |
| 4 | 95 | 0.40 | 0.77 | 19 | empty |
| 5 | 50 | 0.34 | 0.78 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1842 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 543 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 353 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7BV7 · INTS3 complexed with INTS6 · the same entry in another collection · chain A against A, TM-score 1.00
- Q68E01 · AlphaFold monomer V2.0 prediction for integrator complex subunit 3 (Q68E01) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9UL03 · AlphaFold monomer V2.0 prediction for integrator complex subunit 6 (Q9UL03) · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q68E01
- Every structure of UniProt Q9UL03
- Elsewhere: RCSB PDB 7BV7 · PDBe 7BV7 · UniProt Q68E01 · UniProt Q9UL03
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