MolNFT v1 · #174420 · protein
Eucommia ulmoides TPT3, crystal form 2
7BUV · FPS3: “Eucommia ulmoides TPT3, crystal form 2”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #174420 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7BUV
- Type
- protein
- Length
- 2,269 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FPS3
- UniProt
- A0A1L3KPU1
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FPS3 | protein | 330 | 75% helix, 0% strand | A0A1L3KPU1 |
| B | FPS3 | protein | 321 | 73% helix, 0% strand | A0A1L3KPU1 |
| C | FPS3 | protein | 322 | 78% helix, 0% strand | A0A1L3KPU1 |
| D | FPS3 | protein | 325 | 74% helix, 0% strand | A0A1L3KPU1 |
| E | FPS3 | protein | 316 | 74% helix, 0% strand | A0A1L3KPU1 |
| F | FPS3 | protein | 329 | 73% helix, 0% strand | A0A1L3KPU1 |
| G | FPS3 | protein | 326 | 72% helix, 0% strand | A0A1L3KPU1 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 619 | 0.80 | 0.85 | 75 | empty |
| 2 | 652 | 0.76 | 0.82 | 74 | empty |
| 3 | 534 | 0.76 | 0.83 | 66 | empty |
| 4 | 500 | 0.75 | 0.83 | 59 | empty |
| 5 | 897 | 0.74 | 0.78 | 81 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1967 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 1933 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1818 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 687 Ų buried · 6 hydrogen bonds · protein-protein
- C–F · 502 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7BUV · Eucommia ulmoides TPT3, crystal form 2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L3KPU1
- Elsewhere: RCSB PDB 7BUV · PDBe 7BUV · UniProt A0A1L3KPU1
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