MolNFT v1 · #174390 · protein

Crystal structure of trmo

7BTZ · Putative tRNA (ADENINE(37)-N6)-methyltransferase: “Crystal structure of trmo”. X-ray diffraction, 1 ligand (SAH), 2 pockets (best druggability 0.68). MolNFT v1 #174390 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7BTZ
Type: protein
Length: 420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative tRNA (ADENINE(37)-N6)-methyltransferase
UniProt: A0A080VNW8
Ligands: SAH
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative tRNA (ADENINE(37)-N6)-methyltransferase	protein	212	21% helix, 35% strand	A0A080VNW8
B	Putative tRNA (ADENINE(37)-N6)-methyltransferase	protein	208	21% helix, 37% strand	A0A080VNW8

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	448	0.68	0.79	51	SAH
2	362	0.67	0.81	39	SAH

Interfaces

1 interface between chains.

A–B · 3022 Å² buried · 59 hydrogen bonds · protein-protein

Compared structures

7BTZ · Crystal structure of TrmO · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A080VNW8
Elsewhere: RCSB PDB 7BTZ · PDBe 7BTZ · UniProt A0A080VNW8

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