MolNFT v1 · #174388 · protein
The mitochondrial SAM-MDM10 supercomplex in gdn micelle from S.CERE
7BTX · Mitochondrial outer membrane beta-barrel protein: “The mitochondrial SAM-MDM10 supercomplex in gdn micelle from S.CERE”. Electron microscopy, 18 pockets (best druggability 0.85). MolNFT v1 #174388 on GenesisL1: 3D structure, binding…
- PDB
- 7BTX
- Type
- protein
- Length
- 1,268 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial outer membrane beta-barrel protein; Sorting assembly machinery 35 kda…
- UniProt
- E9P977, P14693, P50110, A0A6A5PXD8
- Pockets
- 18 · best druggability 0.85
Structure
electron microscopy · 4 distinct chains · 29% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial outer membrane beta-barrel protein | protein | 348 | 5% helix, 55% strand | E9P977 |
| B | Sorting assembly machinery 35 kda subunit | protein | 299 | 53% helix, 10% strand | P14693 |
| C | Sorting assembly machinery 37 kda subunit | protein | 307 | 54% helix, 5% strand | P50110 |
| L | MDM10 isoform 1 | protein | 314 | 7% helix, 48% strand | A0A6A5PXD8 |
Pockets
18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1079 | 0.85 | 0.86 | 100 | empty |
| 2 | 349 | 0.79 | 0.89 | 48 | empty |
| 3 | 1041 | 0.77 | 0.79 | 102 | empty |
| 4 | 895 | 0.75 | 0.79 | 94 | empty |
| 5 | 165 | 0.57 | 0.82 | 23 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2172 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 1525 Ų buried · 14 hydrogen bonds · protein-protein
- C–L · 975 Ų buried · 2 hydrogen bonds · protein-protein
- A–L · 784 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7BTX · The mitochondrial SAM-Mdm10 supercomplex in GDN micelle from S.cere · the same entry in another collection · chain A against A, TM-score 1.00
- P50110 · AlphaFold monomer V2.0 prediction for sorting assembly machinery 37 kda subunit (P50110) · a predicted model of the same protein · chain C against A, TM-score 0.94
- P14693 · AlphaFold monomer V2.0 prediction for sorting assembly machinery 35 kda subunit (P14693) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9P977
- Every structure of UniProt P14693
- Every structure of UniProt P50110
- Every structure of UniProt A0A6A5PXD8
- Elsewhere: RCSB PDB 7BTX · PDBe 7BTX · UniProt E9P977 · UniProt P14693 · UniProt P50110 · UniProt A0A6A5PXD8
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